Research Roundup: Saving Lives at Birth, US-Africa Leaders Summit, possible Ebola vaccine, and more

The African Leaders Summit highlighted several initiatives to stimulate innovation. Photo: PATH/Gabe BienczyckAs the first-ever US-Africa Leaders Summit came to a close last week, it was clear that the energy around the partnerships between the United States and African nations are strong and building momentum. This was perhaps best exemplified by the enthusiasm in the room as President Obama and the First Lady spoke to a large crowd at the Young Africans Leadership Initiative symposium—an event that illustrated the Summit’s theme of ‘Investing in the Next Generation.’ Forty-five African heads of state gathered with US government officials and advocates to forge a path forward for partnership between the United States and African nations. Importantly, amid these discussions were several calls for initiatives to stimulate science, technology, and innovation as a way to harness African nations’ growing interest and capacity for locally-driven solutions.The summit was a busy few days with a flurry of announcements. We’ve seen over $37 billion in commitments announced by the US government and various stakeholders, including several targeting health issues like malaria, preventable childhood death, and reproductive, maternal, and newborn health. But beyond the state dinners and the official speeches—and the huge array of side events and discussions—what does the Summit really mean for global health innovation? What will its practical impact be? Here are four key takeaways:1. There is a paradigm shift taking place from traditional forms of aid to new multi-sectoral partnerships for developmentAs major US bilateral global health and development programs have shifted (as others have noted) from providing emergency relief toward more sustainable development models based on trade partnerships and private sector investment, support for science and innovation infrastructure and programming is evolving as well. There is growing recognition that new health technologies no longer emerge from one country’s labs or a handful of Western research institutes, but instead from all corners of the globe. This new paradigm was robustly reflected throughout the Summit.2. The United States is ready to shake up the status quo to support innovationAt several Summit events such as the National Academy of Sciences (NAS)-hosted symposium on Innovation and Impact, it was clear just how global the innovation ecosystem has become. National academies for science and technology and new public-private partnerships are growing capacity for innovation and product development in countries that previously had little or none. It is essential to ensure that new tools are acceptable and accessible to the populations that need them and that local research and innovation efforts are supported. Our global system of funding, introducing, and scaling new health tools must adapt to make this a reality. There are signs that the US government recognizes this shift and is ready to explore new ways of promoting innovation—such as leveraging the new US Agency for International Development (USAID) Global Development Lab to support new models of collaboration. Dr. Lona Stoll—director of the Center of Global Solutions at the Lab—called on participants to partner in breaking down barriers to innovation, and to this aim, USAID announced last week that it will be contributing $1.5 million to the World Bank’s regulatory harmonization trust fund to support regulatory harmonization efforts in Africa—a notable start.3. The world is watching: Will these commitments have teeth?The exciting commitments and pledges lauded at the Summit must be more than just words. While many funding and technical assistance commitments were made, in the next few months we’ll see if the United States and its allies in the private sector and other sovereign states fulfill their promises. Many across the health, science, and development sectors are wondering how pledges made this month will be tracked and reported on. In order to bolster global health research and development partnerships with African states, commitments made last week must also be carried forth to other global discussions—such as those around the post-2015 sustainable development goals—in order to maximize their impact.4. To fight threats to health in Africa and elsewhere, we need to act nowAs the White House outlined, in our increasingly interconnected world, the US government needs a coordinated, proactive global health approach that brings the full force of US expertise in research, and innovation to the global fight against disease. There is no example as prescient as the current Ebola outbreak in Western Africa to illustrate the urgent need for strong US government support for an adaptive global health system and investment in new vaccines, drugs, diagnostics, and other global health tools.

“Innovation can’t take place if people say we don’t need new tools,” said Partners in Health Co-founder Paul Farmer at an event sponsored by the Saving Lives at Birth: A Grand Challenge for Development program last week in Washington, DC. And new tools were certainly on display at DevelopmentXChange 2014—a key component of the Saving Lives at Birth program. The DevelopmentXChange is an opportunity for hundreds of bright minds to come together and display groundbreaking prevention and treatment approaches for pregnant women and newborns in low- and middle-income countries. The event is also a time for key policymakers and decision makers to talk about the importance of science, research, and innovation for global health. Saving Lives at Birth—a partnership between the US Agency for International Development (USAID), the Bill & Melinda Gates Foundation, the Government of Norway, Grand Challenges Canada, and the UK Department for International Development—provides funding for a select group of finalists that offer the most innovative new tools. Large crowds were spotted at the DevelopmentXChange Marketplace the morning of the event. The DevelopmentXChange opened up with a marketplace where finalists of the Saving Lives at Birth challenge could display their innovations and demonstrate how these new tools could make a difference in the lives of mothers and children in low-resourced settings. Imagine a giant science fair where, instead of competing for a blue ribbon, the participants are competing for funding to make their innovation a reality. On display were several proposed innovations from GHTC members FHI 360, Jhpiego, and PATH. FHI 360 proposed a synchronized schedule for postpartum women to receive family planning services and for their newborns to receive immunizations and growth monitoring all at the same time. One of the innovations Jhpiego developed was the E-Partogram—an affordable, easy-to-use handheld electronic decision-making tool for preventing and managing complications during labor. PATH was one of many other organizations to address postpartum hemorrhage by developing heat-stabilized oxytocin—a common treatment for hemorrhaging women after childbirth—in a fast-dissolving oral tablet that would treat postpartum hemorrhage.   USAID Administrator Raj Shah addresses the crowd at the DevelopmentXChange Forum After the marketplace, policymakers, scientists, members of the global health community, and the Saving Lives at Birth finalists gathered together for the DevelopmentXChange Forum, which included opening remarks from USAID Deputy Assistant Administrator for Global Health Katie Taylor, USAID Administrator Raj Shah, and Paul Farmer. Administrator Shah commended many of the past year’s innovations for making a real difference in the lives of women and children, and commented on how the Saving Lives at Birth program influenced the creation of USAID’s new Global Development Lab. The rest of the forum featured innovators from all over the world, including past Saving Lives at Birth challenge winners. One of the innovations featured at the forum was a new, low-cost device that assists in delivering babies when complications occur in the second stage of labor. The device—called the Odon Device—was originally thought of by an Argentine mechanic named Jorge Odon when he was thinking about how to get a cork out of a bottle one night. The Odon device is made of a film-like polyethylene material and could be a safer and easier way to deliver complicated births rather than using than forceps or a vacuum extractor. After Mr. Odon partnered with Becton, Dickinson and Company, and received funding from Saving Lives at Birth at last year’s DevelopmentXChange, the Odon Device was finally ready for full development. Now the device is being tested in clinical trials and—if approved—has the potential for wide application in resource poor settings. If there was one thing very apparent during the day, it was that great, life-saving ideas can come from anyone—no matter what they do or where they live. Saving Lives at Birth is a good example of a mechanism that brings governments, foundations, and for-profit companies together to encourage creativity and innovation to tackle some of the world’s most pressing problems. The day concluded with Wendy Taylor—director of USAID’s Center for Accelerating Innovation and Impact—announcing the winners of the Saving Lives at Birth challenge. GHTC members PATH and FHI 360 both won seed grants to get their ideas up and running so that one day they could have the potential to protect and improve the lives of mothers and children all over the world. GHTC congratulates all of the challenge winners and is inspired by every single one of the innovators who were at this year’s DevelopmentXChange.