Global health R&D at work in Ohio
Cincinnati Children’s Hospital Medical Center led early-stage clinical trials of two Shigella vaccine candidates. Worldwide, Shigella causes more than 150 million cases of severe diarrhea and dysentery annually, including 450,000 cases in the United States, and kills an estimated 600,000 people each year, most of whom are young children in low-income countries. Antibiotics are the standard treatment, but drug-resistant strains are spreading at an alarming rate, and no vaccine is yet available—underscoring the importance of continued vaccine development efforts.