News: Advocacy action

GHTC responded to a public request for comment on the pandemic accord negotiations that was released by the US Department of Health and Human Services' Office of Global Affairs. GHTC's comments focused on the need for the accord to feature provisions that incentivize continuous research and development, facilitate equitable access to medical countermeasures, and strengthen regulatory capacity.Global Health Technologies Coalition Recommendations for US Department of Health and Human Services on the Implications of Access and Benefit Sharing (ABS) Commitments/Regimes and Other Proposed Commitments Being Considered Under a WHO Convention, Agreement or Other International Instrument on Pandemic Prevention, Preparedness and ResponseThe Global Health Technologies Coalition (GHTC) is a coalition of more than 45 nonprofit organizations, academic institutions, and aligned businesses advancing policies to accelerate the creation of new drugs, vaccines, diagnostics, and other tools that bring healthy lives within reach for all people.We appreciate the US government, via the Departments of Health and Human Services and State, for providing this consultative opportunity to comment on the ongoing Intergovernmental Negotiating Body (INB) process, the Access and Benefit Sharing (ABS) commitments/regimes, and other research and development (R&D) provisions being considered.Many provisions in the draft agreement are positive, recognizing and affirming key points related to human rights and inclusive provisions that prioritize vulnerable and marginalized populations. The draft recognizes vaccine inequity as a vital concern and affirms key principles of equity and non-discrimination and the need to ensure adequate support for both health workers and the World Health Organization (WHO).However, we believe there are several areas in which the text could be strengthened, particularly when it comes to language around gender equity, a stronger focus of dual-use research and harmonizing pandemic preparedness investments with ongoing efforts to fight malaria, tuberculosis (TB), HIV/AIDS, neglected tropical diseases, and antimicrobial resistance (AMR). There are also ways the draft could be improved to include provisions that address the regulatory ecosystem and the distinct role of WHO.Please find our recommendations below.General CommentsElevate gender equity more broadly throughout the text.The agreement must meaningfully prioritize gender equity. The draft text promotes gender inclusion in areas such as workforce and clinical trials, but it misses other strategic opportunities to advance gender responsive policy essential to equitable pandemic prevention, preparedness and response (PPR). The draft should include specific language affirming the parties’ commitments to collect, report, and analyze data disaggregated by gender, ethnicity, race, and age, and uphold social protections and the full spectrum of essential health services for all during health emergencies.Broaden to all stages of R&D.The text focuses very heavily on later stages of R&D rather than all stages needed for preparation and response. Despite member state proposals to widen the focus to include early-stage collaboration, there are no provisions relating to early-stage R&D activities, including discovery research, where investments and collaboration are needed. Specific provisions should be added to Article 9 (Research and Development).Article 9: Research and DevelopmentLeveraging investments for PPR for health systems strengthening.While the agreement includes language that highlights the interconnectedness of health system strengthening and PPR, it lacks provisions that underscore the need to focus on sustainability and “dual-use” R&D capacity and infrastructure that can be leveraged for both pandemic response and longstanding challenges. Article 9 (Research and Development) should therefore add language that explicitly highlights that building clinical trial and laboratory capacity and networks to address ongoing epidemics like HIV/AIDS, TB, malaria, and polio; re-occurring outbreaks of Ebola, Marburg, and cholera; and AMR contributes to both pandemic preparedness and overall health system strengthening.Greater coordination between regulatory authorities and ethics committees for clinical trials.The role of regulatory authorities extends beyond regulatory approvals for market-ready health tools. Conduct of clinical trials requires approvals from regulatory authorities and ethics committees as well. Regulatory authorities and ethics committees, working in a coordinated way to grant approvals, especially during a public health emergency, will speed up the conduct of clinical trials. Article 9 should add a provision under its clinical trials section that promotes greater coordination between ethics committees and regulators. We urge the United States to push for new language encouraging and incentivizing joint reviews of regulatory dossiers, which will maximize opportunities for cooperation between countries and can help optimize review timelines by allowing regulatory authorities to share data, validate findings, and streamline communications with the applicant, thereby expediting market access to the health tools developed.The role of WHO.The pandemic agreement should ensure that WHO is sufficiently empowered to play a strong normative role in helping define a priority research agenda and in coordinating research, building on the R&D Blueprint, to speed innovation and avoid unnecessary duplication and fragmentation of data.Article 10: Sustainable ProductionGoing beyond rapid manufacturing scale-up.Pandemic prevention and response is too often marked by cycles of panic and neglect. While Article 10 (Sustainable Production) outlines provisions that seek to strengthen manufacturing capacity, as well as more diverse and regionally distributed production capabilities to respond during an emergency, the draft currently does not cover incentivizing continuous research to develop vaccines, diagnostics, therapeutics, and other health technologies for epidemic-prone diseases that disproportionately impact low- and middle-income countries. A greater focus needs to be placed at looking beyond just rapid scale-up of production capacity during an emergency, to instead supporting sustained research into disease threats during “times of peace”. Continuous research can yield discoveries that accelerate the development of medical countermeasures for novel pathogens, as was the case when prior research on an mRNA vaccine for HIV contributed to speeding up the development of mRNA COVID-19 vaccines. A provision should be added for supporting such research.Incentivize expanded registration of pandemic tools to accelerate equitable access.To ensure timely global access to health tools developed, manufacturers must seek regulatory approvals or authorizations beyond high-income countries, particularly in developing countries where transmission is high and clinical trials have been conducted, to ensure fair and equitable access to the fruits of research. Therefore, Article 10 (Sustainable Production) should include new text that calls on countries to provide incentives for manufacturers to facilitate this, with a view to achieving a more equitable geographical distribution of the global production of pandemic-related products.Article 11: Transfer of technology and know-howArticle 12: Access and benefit sharingEquitable access to medical countermeasures.The agreement must maintain language on global public health and equitable access at the center of policies, processes, and investments. This means ensuring low- and middle-income countries can create, manufacture, and buy countermeasures when needed and have the resources to respond quickly. Commitments to equitable access in Articles 11, 12, and 13 must be enshrined through robust language on distributed manufacturing capacity, technology transfer, and access and benefit sharing.Regulatory policy that enables innovation and access.The framework should include provisions strengthening the capacity of regional regulatory bodies, like the newly formed African Medicines Agency. Investing in bolstering the regulatory capacity of these regional bodies, and not just promoting harmonization, will help fill gaps for countries with lower regulatory maturity levels. Text should be included that standardizes policies or protocols for the regulation of products during health emergencies. Currently, the draft only highlights general regulatory harmonization and focuses on licensing of pandemic products, without taking into account broader elements of the regulatory ecosystem.

GHTC contributed to statements delivered by the Global Health Council at the 154th World Health Organization (WHO) Executive Board (EB) meeting on global health R&D agenda items: neglected tropical diseases (NTDs), tuberculosis (TB), and antimicrobial resistance (AMR). More of GHTC's recommendations to policymakers ahead of the EB are available here.

January 4, 2024 The Honorable Charles Schumer The Honorable Mike Johnson Majority Leader Speaker United States Senate U.S. House of Representatives Washington, DC 20510 Washington, DC 20515 The Honorable Mitch McConnell The Honorable Hakeem Jeffries Minority Leader Minority Leader United States Senate U.S. House of Representatives Washington, DC 20510 Washington, DC 20515 Dear Speaker Johnson, Majority Leader Schumer, Minority Leader McConnell, and Minority Leader Jeffries: The 850 undersigned organizations—representing the full breadth of diverse programs that support all of America, every day—are extremely alarmed by the possibility for very deep cuts to all of these non-defense programs (often referred to as non-defense discretionary appropriations or simply “NDD”) for fiscal year 24 (FY24) if a full-year continuing resolution were to pass. Such cuts would be disastrous for the capacity of the federal government to serve the public, assist those in need, fuel innovation, and address national and global threats. We strongly urge Congressional leadership to instead finish the FY24 appropriations process and adopt the bipartisan Senate funding framework as a starting point for final negotiations. Vital domestic and international appropriations are a small part of the federal budget—less than one-sixth—yet they fund a wide range of important programs and services that make America run and strengthen our economy. Examples include investments in: scientific and medical research; medical care for veterans; environmental protections; home energy assistance; assistance with housing and child care for low-income families; rural development; K-12 education and skills training; nutrition assistance for young children, families, and older people; financial aid for college students; infrastructure investments in things like transportation choices, sewage treatment, safe drinking water, flood control and navigation improvements; diplomacy, humanitarian aid and development; services for victims of gender-based violence; courts and reentry programs; assistance for small businesses; public safety and other programs for older people; public health; and many more. Republicans and Democrats have historically supported these programs because every state and congressional district in the country benefits from NDD investments. Walking away from these investments would be walking away from the constituents — children, families, seniors, people with disabilities, students, and workers, in rural, suburban and urban communities — Congress has taken an oath to serve. Enacting the FY24 NDD cap of $704 billion included in the Fiscal Responsibility Act by passing a full-year CR for all 12 spending bills would mean reducing NDD spending by as much as 9 percent according to the Center on Budget and Policy Priorities. The cuts would be enacted over the course of nine months or less instead of a full year, making them even more dramatic and painful. The results of these cuts would be catastrophic for the American people and violate the agreement Congress made with the White House in June to lift the debt ceiling. The full terms sheet of the debt ceiling compromise must be honored in the FY24 process. Together we call on Congress to finish the FY24 appropriations process adhering to the agreement reached on behalf of the American people, moving funding packages with the necessary funds and without including dangerous poison pill policy riders. We urge Congressional leadership to adopt the bipartisan appropriations approach the Senate pursued in July as an example of the type of across-the-aisle collaboration the American people expect to ensure the programs they rely on are funded in a manner that allows them to provide the services they need. We also ask that you come to an agreement on funding other urgent spending priorities quickly so we can turn our collective attention to FY25. Sincerely, 350.org A Better Way Services, Inc. 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