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Global health R&D delivers for Minnesota

US government investment in global health R&D has delivered

$32.8 million
to Minnesota research institutions
400+ new jobs
for Minnesota
Global health R&D at work in Minnesota

Researchers at the University of Minnesota Medical School are working to unlock why antiretroviral therapies are unable to completely shut down HIV production in cells in certain parts of the body. According to their research, nearly 99 percent of these HIV-infected cells are found in tissue in the lymph nodes, spleen, and gastrointestinal tract. This reservoir of latently infected cells can reactivate if therapy is interrupted, posing a major challenge to curing the disease. Their key finding was that these cells are associated with lower concentrations of drugs in these tissues. A next step is to understand why current treatments do not reach adequate levels in lymphoid tissue. This knowledge could lead to development of more effective treatments for HIV or even a cure for AIDS. Globally, more than 36 million people are living with HIV.

  • Methodology
  • USG global health R&D investment to state research institutions/Top USG-funded global health R&D institutions: Authors' analysis of USG investment data from the G-FINDER survey, including funding for R&D for neglected diseases from 2007–2015 and for Ebola and select viral hemorrhagic fevers from 2014–2015. Reflects USG funding received by entities in state including academic and research institutions, product development partnerships, other nonprofits, select corporations, and government research institutions, as well as self-funding or other federal agency transfers received by federal agencies located in state; but excludes pharmaceutical industry data which is aggregated and anonymized in the survey for confidentiality purposes. See methodology for additional details.
  • Jobs created: Based on previous analysis of the economic impact of National Institutes of Health R&D funding and author's analysis described above. See methodology for additional details.
  • Case study photo: PATH/Evelyn Hockstein