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Global health R&D delivers for South Dakota

US government investment in global health R&D has delivered

$1.2 million
to South Dakota research institutions
Global health R&D at work in South Dakota

Researchers at South Dakota State University are part of a consortium of global organizations working to develop a vaccine against enterotoxigenic E. coli, or ETEC, a deadly diarrheal disease. The scientists altered the toxins produced by a form of E. coli and genetically fused this non-poisonous "toxoid" to a protein known to evoke an immune response. The resulting "fusion protein" could be used to develop a vaccine. Besides causing diarrheal illness in farm animals, ETEC is a main source of bacterial-induced diarrhea in low-income countries and is the chief cause of traveler's diarrhea. Unsafe water sources and lack of adequate sanitation increase the risk of contracting ETEC. The World Health Organization estimates that ETEC causes approximately 210 million cases of illness in humans and 380,000 deaths each year, most of whom are young children.

  • Methodology
  • USG global health R&D investment to state research institutions/Top USG-funded global health R&D institutions: Authors' analysis of USG investment data from the G-FINDER survey, including funding for R&D for neglected diseases from 2007–2015 and for Ebola and select viral hemorrhagic fevers from 2014–2015. Reflects USG funding received by entities in state including academic and research institutions, product development partnerships, other nonprofits, select corporations, and government research institutions, as well as self-funding or other federal agency transfers received by federal agencies located in state; but excludes pharmaceutical industry data which is aggregated and anonymized in the survey for confidentiality purposes. See methodology for additional details.
  • Case study photo: PATH/Aaron Joel Santos